Zepbound Cost Without Insurance in 2026: Self-Pay, Savings Card and Medicare

01 Price by dose

How Much Is Zepbound Without Insurance? Price by Dose

Lilly sells Zepbound for cash through LillyDirect at one price per dose, whether you get the 4-dose KwikPen or a month of single-dose vials. The lower $449 tier for 7.5 mg and up applies only if each refill is completed within 45 days of the last delivery. Miss that window and 7.5 mg costs $499 while 10 to 15 mg costs $699.

Each fill is a 1-month supply: one KwikPen with 4 weekly doses, or 4 single-dose vials. The label lists 5 mg, 10 mg and 15 mg as maintenance doses; your prescriber sets the dose. Prices as of Oct 2026.

02 The math

Zepbound Cost for the First Year

The label starts everyone at 2.5 mg for 4 weeks and raises the dose by 2.5 mg no sooner than every 4 weeks. The table below assumes the fastest climb to 15 mg and 13 fills in 52 weeks.

Past 7.5 mg the dose no longer changes the price, so 10 mg and 15 mg maintenance cost the same $5,637 a year. The 45-day rule is worth $2,550 a year at maintenance doses, so a refill reminder pays for itself. At TrumpRx's $1,087 original price, 13 fills would run about $14,131.

03 LillyDirect

LillyDirect Zepbound: How the Self-Pay Offer Works

LillyDirect is Lilly's own online pharmacy and telehealth hub; it is where the $299 to $449 cash prices live. You still need a prescription from a US prescriber, either your own doctor or a telehealth clinic.

1. 01

   Get a prescription for the KwikPen or vials.

   The self-pay offer covers "a 1-month prescription of the Zepbound KwikPen for single-patient use or 4 vials." It does not cover the single-dose Zepbound Pen (autoinjector).

2. 02

   Have it sent to LillyDirect.

   The prescriber sends it to LillyDirect Pharmacy, which ships it to your home.

3. 03

   Pay by dose.

   $299 at 2.5 mg, $399 at 5 mg, $449 at 7.5 mg and up with an on-time refill.

4. 04

   Refill within 45 days.

   The clock runs from the delivery or receipt date of your last fill. After 45 days the regular price applies: $499 for 7.5 mg, $699 for 10 to 15 mg.

5. 05

   Medicare patients can pay cash too.

   Lilly's page notes that Medicare patients can also choose self-pay at the same prices.

LillyDirect Customer Care, 844-559-3471, 9am to 7pm ET, Monday to Friday (as listed on TrumpRx.gov, Oct 2026).

04 Savings card

Zepbound Savings Card 2026: Who Pays $25

The Zepbound savings card is for people with commercial insurance; government-insured patients (Medicare, Medicaid, TRICARE and similar) are excluded. The 2026 card expires and savings end on December 31, 2026; Lilly had not published 2027 terms as of Oct 17, 2026.

How much does Zepbound cost with insurance?

With coverage, your real cost is your plan copay minus the card, as low as $25 a month until you hit the $1,300 yearly cap. Coverage itself depends on your employer: in KFF's 2025 survey, 43% of firms with 5,000+ workers covered GLP-1s primarily for weight loss (28% in 2024).

Prior authorization steps: Zepbound insurance guide. Plan-by-plan picture: GLP-1 cost with insurance.

05 Cheapest way

Cheapest Way to Get Zepbound Without Insurance

Ranked from lowest to highest monthly cost as of Oct 2026. Pick the first line that fits you.

1. $50

   1. Medicare Part D and you qualify: $50/mo.

   The CMS Medicare GLP-1 Bridge charges $50 a month for the Zepbound KwikPen (not vials) from Jul 1, 2026 to Dec 31, 2027, if you meet a BMI tier. Details: Medicare GLP-1 Bridge.

2. $25

   2. Commercial plan that covers it: $25/mo.

   Use the savings card on top of your plan, up to $1,300 a year.

3. $299+

   3. No coverage: LillyDirect self-pay, $299 to $449.

   Refill within 45 days every time; at 7.5 mg and up that saves $50 to $250 a month versus a late refill.

4. $299+

   4. Same price, different door: TrumpRx.gov.

   TrumpRx lists the same $299 / $399 / $449 tiers and sends you to LillyDirect to order; it adds no second discount. See TrumpRx GLP-1 prices.

5. +fee

   5. Telehealth clinic: drug price plus a fee.

   Useful if you need a prescriber; the clinic adds a membership on top of Lilly's price (table below).

6. $499+

   6. Retail cash at Costco: higher.

   Costco lists the KwikPen at $499.22 (2.5 to 7.5 mg) and $699.21 (10 to 15 mg).

06 Three cash prices

Zepbound at LillyDirect, TrumpRx and Costco

Same drug, three cash prices. Bars scale to $699.21 (100%).

LillyDirect prices from zepbound.lilly.com, Oct 17, 2026; TrumpRx.gov Zepbound page, Oct 17, 2026; Costco from the rx.costco.com price tool, Oct 17, 2026 (Costco also shows a second KwikPen listing at $495.45 and $693.93). Costco cash prices cannot be combined with insurance or Medicare claims. Store-by-store guide: Costco GLP-1 prices.

07 Telehealth

Telehealth Providers That Prescribe Zepbound: Monthly Totals

Clinics charge Lilly's self-pay price for the drug and add their own fee. Totals are fee plus medication, from each provider's published prices as of Oct 17, 2026.

Reviews: Ro GLP-1 reviews, PlushCare review. More clinics: best GLP-1 providers 2026. Ordering online step by step: Zepbound online.

08 Versus Wegovy

Zepbound vs Wegovy Cost

Wegovy is about $1,400 cheaper in year one on self-pay; tirzepatide showed more weight loss in its own trial, and in the head-to-head SURMOUNT-5 trial. Full numbers: Wegovy cost and Zepbound vs Wegovy.